Cardiff School of Biosciences PhD Studentship in Pathophysiology and Repair (PhD Studentship)
Reference Number: R1121
Key Studentship Information
Project Title: Small molocule mediated enhanced of hematopoietic stem and progenitor cell function in vitro and in transplantation
Project Description: Hematopoietic stem and progenitor cells (HSCs and HPCs respectively) have been effectively exploited in medical practice where they are routinely used in bone marrow (BM) and cord blood (CB) transplantation to treat blood cancers. However, there are still several unresolved, important clinical issues in transplantation, including: (i) overcoming the small number of HSCs and HPCs in CB that can limit the procedure of CB transplants in adults and (ii) overcoming potentially fatal infections caused by delayed recovery of HSC function following transplantation. This studentship is focused on candidate small molecules with the potential to solve these issues, which, overall, could improve treatment for blood cancers. The student will perform a detailed cellular and molecular characterisation of candidate small molecules using a variety of in vitro and in vivo models mimicking the clinical context of BM and CB transplantation. In parallel, the candidate will also evaluate whether candidate small molecules will augment production of HSCs/HPCs from other cell sources (e.g. embryonic or induced pluripotent stem cells) that could eventually be used in transplantation.
Start date: 1st January 2014
The award consists of UK/EU fees and a maintenance stipend. This will be £13,726 in the first year and is likely to increase in subsequent years.
Number of awards: 1
Academic Criteria: Applicants will need a 2:1 degree (or equivalent) in a relevant subject, or a 2:2 degree plus a Master's degree (or equivalent qualifications). For English language requirements please see our website.
Residency: This studentship is open to UK and EU citizens.
How to Apply
To make an application please submit an aonline application for PhD study with the School of Biosciences using our online application service. Please clearly indicate on your application that you woulld like to be considered for this project.
For more information on how to apply please see the biosciences website.
Application Deadline: 15th November 2013
For more information please contact Swapna Khandavalli on KhandavalliS@cardiff.ac.uk or +44 (0)29208 75243.