Cardiff School of Dentistry PhD Studentship: Investigating the Potential of Oral Progenitor Cell Populations for the Treatment of Chronic Disease (PhD Studentship)
Reference Number: R826
Key Studentship Information
Project Title: Investigating the Potential of Oral Progenitor Cell Populations for the Treatment of Chronic Disease
Project Description: Stem cells hold much promise for the repair and regeneration of damaged and diseased tissues. Our recent work has resulted in the isolation of a novel, stem cell population from the oral mucosa. We have demonstrated that oral mucosal progenitor cells (OMLP-PCs) are both multi-potent and actively immunosuppressive suggesting that they may be beneficial in both tissue engineering applications and directly in the treatment of immune related disorders. This PhD project will further investigate the properties of these OMLP-PCs, focussing on their potential for the treatment of immune related and infectious diseases.
This project will contribute to our growing portfolio of Research Council funded stem cell projects and our international patent filings regarding the isolation and characterisation of OMLP-PCs. This project sits firmly with ongoing research projects in both the Wound Biology Group (P. Stephens and L. Davies) and Mineralised Tissue Group (A. Sloan), meaning that the student will be well supported by numerous postdoctoral researchers and postgraduate students already working in the field of stem cell biology. Both groups are well funded (Research Council funding) and resourced. The student will also be supported in the laboratory by a recently appointed technician who will provide half-time lab support for research in this area.
The student will have an opportunity to develop a wide range of laboratory technical skills during the project (e.g. tissue culture, microbiology) allowing the development of extensive cross disciplinary technical skills equipping the student well for their future career. As the project develops there will also be the opportunity to develop knowledge in both protein and molecular biology, with the student learning RT-PCR, siRNA and electrophoretic techniques such as SDS-PAGE/Western Blotting and proteomics.
About the School of Dentistry: The primary research objective of the School is to produce internationally competitive research of the highest standards and relevance to dentistry. The School of Dentistry, Cardiff University provides a thorough training programme for all its postgraduate students to support their research career development. The School boasts excellent wet laboratory facilities, including large modernised tissue culture suites, light and fluorescent microscopy facilities (with digital image acquisition), automated time-lapse microscopy, scanning electron microscopy, confocal microscopy, image analysis resources, protein purification and molecular biology facilities (real-time PCR, radiolabelled in situ hybridisation, DNA sequencing). Interdisciplinary research is a major part of the School’s strategy, which is strengthened through collaborations with complementary research disciplines at local, national and international levels.
Please see the School of Dentistry website for further details.
Supervisors: P Stephens, L Davies and A Sloan
Number of Awards: 1
Successful applicants will receive Full UK/EU tuition fees plus a doctoral stipend matching UK Research Council National Minimum (£13,5 90 p.a. for 2010/11, updated each year).
Academic Criteria: Applicants must hold a minimum 2.1 undergraduate degree in a biological/biomedical subject area. Relevant Masters experience would also be advantageous.
Residency: Full awards (fees plus maintenance stipend) are open to UK Nationals, and EU students who can satisfy UK residency requirements. To be eligible for the full award, EU Nationals must have been in the UK for at least 3 years prior to the start of the course for which they are seeking funding, including for the purposes of full-time education. EU Nationals who do not meet the above residency requirement are eligible for a fees-only award, provided that they have been ordinarily resident in the EU for at least 3 years prior to the start of their proposed programme of study.
How to Apply
No separate application is necessary, consideration is automatic upon applying for postgraduate study. Applications for the PhD programme can be made using Cardiff's online applications service. Please indicate that you would like to be considered for this studentship in the funding section of the application form.
Application Deadline: 11th May 2012