PhD Studentship in New Implant Material (PhD Studentship)
Reference Number: R2223
Project title: Functional and Biological Assessment of a New Implant Material to Treat Focal Cartilage Defects
This studentship will be undertaken in the prestigious Arthritis Research UK Biomechanics and Bioengineering Centre in Cardiff University and the successful candidate will benefit from the Centre's unique interdisciplinary tools, expertise and working environment.
This project will investigate biological and functional properties of a new implant, called BioPoly both in vitro and in humans. BioPoly is an osteochondral replacement device made from a novel microcomposite of ultra-high molecular weight polyethylene (UHMWPE) and cross-linked hyaluronan (HA). Developed to address surgical, biological and mechanical deficiencies in current treatments for focal cartilage defects, the surgical advantages of BioPoly include broader applications (failed microfractures, patients who are older), faster post-operative rehabilitation, tissue sparing and pain reduction, and weight bearing immediately post-operatively. It provides an instantly usable bearing surface enabling immediate anatomically loaded, articulation, and unlike current treatments (eg. OATS, ACI/MACI and microfracture), will tolerate knee malalignment.
The objectives of the project are to (1) Assess biological, biomechanical, functional and imaging biomarkers in patients given BioPoly implants pre and post-operatively by longitudinal assessment of patients pre/post-operatively, and (2) Assess BioPoly implant responses in in vitro models of mechanically-loaded bone/cartilage
Supervisors: Dr C A Holt
Start date:1 April 2014
Number of Studentships: 1
This studentship consists of full UK/EU tuition fees, as well as a Doctoral Stipend matching UK Research Council National Minimum (£13,863 p.a. for 2014/15, updated each year).
One studentship is available.
This studentship is open to students of any nationality. Students classified as international for fee purposes have to self-fund the difference between home and international fees.
Academic criteria: Applicants for a studentship must have obtained, or be about to obtain, a 2.1 degree or higher in a relevant subject. Applications are particularly welcome from applicants with a good first degree or Masters qualification in Engineering or Bioscience.
How to Apply
In the first instance, you should submit a CV & Covering Letter to Miss J Cleaver at: firstname.lastname@example.org. Please ensure that you quote the studentship reference NRN-CH-2014 in the email subject field.
The successful candidate will then be invited to submit a standard application for Postgraduate Study via the Online Application Service.
The deadline for all applications is February 28th 2014.